Ovarian Cancer Therapeutics in Asia-Pacific Markets to 2020 - Off-patent Chemo-regimens to Retain Dominance Despite New Launches

Ovarian Cancer Therapeutics in Asia-Pacific Markets to 2020 - Off-patent Chemo-regimens to Retain Dominance Despite New Launches

GBI Research, a leading business intelligence provider, has released its latest research report, "Ovarian Cancer Therapeutics in Asia-Pacific Markets to 2020 - Off-patent Chemo-regimens to Retain Dominance Despite New Launches". The report provides estimates of the market size for 2013, along with forecasts until 2020 for the Asia-Pacific markets of India, China, Australia and Japan. It also covers disease epidemiology, treatment algorithms, treatment patterns, in-depth analysis of clinical trials including failure rates and pipeline analysis, and analysis of deals relevant to Ovarian Cancer (OC).

Platinum-based chemotherapy, predominantly the chemotherapy regimen paclitaxel and carboplatin, is the standard of care for the treatment of platinum-sensitive OC (both first-line and recurrent). The initial treatment is quite effective, with the majority of patients entering remission. However, almost all relapse, and after successive periods of remission and relapse either die or progress to platinum-resistant disease, for which the prognosis is poor. There is a clear gap in the market for maintenance therapies, as well as for more effective treatment options in platinum-resistant or refractory patients.

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Although the current developmental pipeline is quite crowded, efficacy with these late-stage drugs has been poor, at best demonstrating minimal improvements in progression-free survival, but not overall survival. The promising investigational drug candidates olaparib and trebananib are expected to gain approval during the forecast period. However, even on approval they are not expected to have a high market penetration, owing to their minimal therapeutic efficacy and anticipated premium prices. As a result, the OC market in APAC is expected not be driven by new drug approvals, but primarily by inflation, and the increase in the prevalence of OC. Market revenue is forecast to rise at a limited CAGR of 5.1% to 417.6m in 2020.

Despite the poor clinical performance of current late-stage pipeline drugs, there is evidence of continued interest in the OC market, with a high number of drug candidates in the initial developmental pipeline, particularly at the Preclinical phase. There is a wide range of novel molecular targets distributed among these drug candidates, including growth factors, serine/threonine protein kinases and tumor associated antigens. This suggests a continued interest in introducing more targeted therapies into the treatment of OC, the use of which in this indication lags significantly behind that in others in oncology.


The report analyzes treatment usage patterns, drug types available and pipeline and market forecasts for OC. It covers and includes - 
- A brief introduction to OC, including the disease’s pathogenesis, risk factors and diagnosis
- In-depth analysis of the drug combinations used in the treatment of OC, including analyses of their safety, efficacy, and place in the disease treatment algorithm, as well as a heat map comparing the drug combinations in terms of safety and efficacy
- A comprehensive review of the pipeline for OC therapies, including individual analysis of a number of late-stage pipeline drugs that have the potential to enter the market in the forecast period; the pipeline is analyzed on the basis of phase distribution, molecule type and molecular target, and route of administration
- Additional in-depth analysis of pipeline drug clinical trials by phase, molecule type, trial size, and trial duration, and program failure rate analyses for each molecule type and mechanism of action
- Multi-scenario forecast market data to 2020, taking into account how it will be affected by the introduction of new drugs, the expiry of key patents on current drugs, and the changes in disease epidemiology across the APAC markets
- Discussion of the drivers and barriers for market growth
- In-depth analysis of licensing and co-development deals involving drugs indicated in OC, including an outline of the key deals

Reasons to buy

The report will assist business development and enable marketing executives to strategize their product launches, by allowing them to - 
- Understand the efficacy and safety of the current monotherapies and drug combinations used in the treatment of OC, with in-depth analysis of the disease treatment algorithm
- Understand the key signaling pathways and molecular targets currently under investigation in OC drug development
- Understand the vast scope of the pipeline, including which molecule types and mechanisms of action are prominent
- Observe the trends in clinical trial duration and size among clinical phases and molecule types, and use the clinical trial failure rate analysis to assess the risk profiles of current and/or future developmental programs for OC therapeutics
- Assess the potential clinical and commercial impact of current late-stage pipeline molecules in the OC therapeutics market

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Table of Content

1 Table of Contents
1 Table of Contents 5
1.1 List of Tables 7
1.2 List of Figures 7
2 Introduction 9
2.1 Disease Pathophysiology 9
2.1.1 Ovarian Cancer – A Group of Distinct Diseases 9
2.1.2 Ovarian Cancer is Highly Heterogenic with Multiple Mutations and Affected Signaling Pathways 10
2.2 Symptoms and Diagnosis 12
2.3 Risk Factors 14
2.3.1 Age 14
2.3.2 Inherited Genetic Mutations 14
2.3.3 Greater Number of Lifetime Ovulations 14
2.3.4 Weight 14
2.3.5 Previous Medical Conditions 14
2.4 Treatment Algorithm 14
2.4.1 Surgery 14
2.4.2 First-Line Chemotherapy 15
2.4.3 Maintenance Therapy 18
2.5 Recurrent Disease 20
3 Marketed Products 38
3.1 Carboplatin 38
3.2 Paclitaxel 39
3.3 Gemcitabine 40
3.4 Topotecan 41
3.5 Pegylated Liposomal Doxorubicin 41
3.6 Yondelis 42
3.7 Avastin 42
4 Product Pipeline 44
4.1 Overview of Pipeline by Phase and Route of Administration 44
4.2 Overview of Pipeline by Molecule Type, Mechanism of Action and Molecular Target 46
4.2.1 Molecular Targets in the Developmental Pipeline 48
4.3 Clinical Trials 51
4.3.1 Clinical Trial Duration 52
4.3.2 Clinical Trial Size 54
4.3.3 Failure Rate 55
4.3.4 Discussion 57
4.4 Late-Stage Drugs in Developmental Pipeline 57
4.4.1 Niraparib 57
4.4.2 Olaparib 58
4.4.3 Vargatef 60
4.4.4 Trebananib 61
4.4.5 Farletuzumab 65
4.4.6 Karenitecin 66
4.5 Discussion 73
5 Market Forecasts 74
5.1 Asia-Pacific 74
5.1.1 Overview 74
5.1.2 Treatment Use Patterns and Revenues in Asia-Pacific Markets 74
5.2 India 76
5.2.1 Treatment Use Patterns 76
5.2.2 Annual Cost of Therapy 76
5.2.3 Market Forecast 77
5.3 China 78
5.3.1 Treatment Use Patterns 78
5.3.2 Annual Cost of Therapy 78
5.3.3 Market Forecast 79
5.4 Japan 80
5.4.1 Treatment Use Patterns 80
5.4.2 Annual Cost of Therapy 80
5.4.3 Market Forecast 81
5.5 Australia 82
5.5.1 Treatment Use Patterns 82
5.5.2 Annual Cost of Therapy 83
5.5.3 Market Forecast 84
5.6 Drivers and Barriers 85
5.6.1 Drivers 85
5.6.2 Barriers 86
6 Deals 87
6.1 Licensing Deals 87
6.1.1 Clovis Oncology Enters into Licensing Agreement with Pfizer for PF-01367338 89
6.1.2 PharmaMar Enters into Licensing Agreement with Janssen for Yondelis 89
6.1.3 Hana Enters into Licensing Agreement with Tekmira 90
6.1.4 AstraZeneca Enters into Licensing Agreement with Merck for MK-1775 90
6.1.5 Tesaro Enters into Licensing Agreement with Merck Sharp & Dohme for Cancer Drug 90
6.1.6 Oasmia Enters into Licensing Agreement with Medison for Paclical 91
6.1.7 Orion Enters into Agreement with Oasmia 91
6.1.8 Ohio University Enters into Licensing Agreement with Phosplatin 91
6.1.9 Genta Enters into Licensing Agreement with Daiichi Sankyo 91
6.1.10 Celldex Enters into Licensing Agreement with the Ludwig Institute for Cancer Research 92
6.1.11 NanoCarrier Enters into Licensing Agreement with Kowa for NC-6300 92
6.2 Co-development Deals 92
6.2.1 Bristol-Myers Squibb Enters into Co-development Agreement with Ono Pharma 94
6.2.2 Merck Enters into Co-development Agreement with Endocyte for Cancer Drug 94
6.2.3 Pfizer Enters into Research Agreement with BC Cancer Agency and Vancouver Prostate Centre 94
6.2.4 Almac Discovery Enters into an Agreement with Queen’s University Belfast for Drug Discovery 95
7 Appendix 96
7.1 All Pipeline Drugs by Phase 96
7.1.1 Discovery 96
7.1.2 Preclinical 97
7.1.3 IND/CTA-Filed 102
7.1.4 Phase I 103
7.1.5 Phase II 106
7.1.6 Phase III 111
7.1.7 Pre-Registration 111
7.2 Market Forecasts to 2020 112
7.2.1 Asia-Pacific 112
7.2.2 India 112
7.2.3 China 113
7.2.4 Japan 113
7.2.5 Australia 114
7.3 Abbreviations 115
7.4 Bibliography 117
7.5 Research Methodology 122
7.5.1 Coverage 122
7.5.2 Secondary Research 123
7.5.3 Primary Research 123
7.5.4 Therapeutic Landscape 124
7.5.5 Geographical Landscape 126
7.5.6 Pipeline Analysis 126
7.6 Expert Panel Validation 126
7.7 Contact Us 126
7.8 Disclaimer 126

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