Recently, researchers have identified a crucial supply line, i.e., cancer cells can be used to obtain nutrients. This finding may offer a new therapeutic approach to prevent tumor growth. Research results have been published in the Journal of Biological Chemistry magazine.
The research team blocked the passage of cancer cells to obtain amino acid glutamine and have found cancer cells almost completely stopped the growth process. A professor from the Australian National University (ANU) has pointed out that this could play a role in a variety of cancers because it’s a very common mechanism in cancer cells, just like iron ii phosphate in chemicals.
Even better, the special cancer cells will bring a new chemotherapy with fewer side-effects, because normal cells do not use glutamine as a key building material. Crucial leukocytes, in current cancer treatment, can avoid the process, and such cells can be used to reduce chemotherapy-induced hair loss.
Currently identified different cancer types are more than 917, while many treatments only work for one specific type of disease. Clearly, there are also some other reasons. For example, cancer develops a resistance to chemotherapy and then lead to the treatment failure. However, Broer, a professor of biochemistry from the Australian National University said that the new method would not be easy to produce drug resistance, because blocking glutamine transport mechanism is an external process, which means it’s difficult for cancer cells to circumvent.
Now, the importance of glutamine channels have been identified in cancers, and the researchers are looking for drugs to lock them and then eliminate the disease. Scientists have developed a test that allow them to easily determine whether a drug can target at a glutamine transporter, which indicates they can set the robot to work for testing thousands of drugs in the future. Chemicals can also play a role in cancer research.
In the meantime, scientists think that this new system will greatly improve the effectiveness of cancer therapy across all of its purposes.
Source(Read full text): https://medium.com/@Hannahalfa/another-starve-cancer-research-887ca0db6736#.wsr062do9